Regulatory effects of C5a on IL-17A, IL-17F, and IL-23

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Regulatory effects of C5a on IL-17A, IL-17F, and IL-23

The complement anaphylatoxin, C5a, through binding to its receptors (C5aR or C5L2), has important biological properties for recruitment and activation of phagocytes. C5a has been identified as a powerful modulator of Toll-like receptor-induced cytokine and chemokine production by macrophages. Both the complement system and the interleukin (IL)-17 cytokine family protect against extracellular pa...

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Clinical Significance of IL-23 Regulating IL-17A and/or IL-17F Positive Th17 Cells in Chronic Periodontitis

OBJECTIVE To investigate the expression level and clinical significance of (IL-17A(+) and/or IL-17F(+)) Th17 cells under IL-23 regulation in patients of chronic periodontitis (CP) and healthy controls (HC). MATERIALS AND METHODS The whole peripheral blood samples were collected from 30 CP patients and 25 healthy controls. Flow cytometry was used to test the (IL-17A(+) and/or IL-17F(+)) Th17 e...

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Correlation between acute myeloid leukemia and IL-17A, IL-17F, and IL-23R gene polymorphism.

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Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes.

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ژورنال

عنوان ژورنال: Frontiers in Immunology

سال: 2013

ISSN: 1664-3224

DOI: 10.3389/fimmu.2012.00387